Good question. I don’t know the exact answer (is there an exact answer for anything in technology?), but this article does a really good job of covering common sense approaches to site collection governance and MOSS. There are a few issues — what if you need to rollup content across site collections — but most of it is straight forward advice.
Patrick Neeman is Director of User Experience at Jobvite, a social recruiting platform and runs both the UX Drinking Game and Startup Drinking Game | More | Contact